We predict, qualitatively, the structural transitions in microemulsion systems induced by nonionic polymers, by virtue of their ability to associate with the surfactant assemblies. The predictions are made possible by linking (a) theoretical calculations of the domains of existence of oil-in-water (O/W) and water-in-oil (W/O) droplet microemulsions with (b) the experimental observation that on ...

BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising ...

The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated ...

OBJECTIVE To investigate the cellular uptake of evodiamine and rutaecarpine in a microemulsion in comparison with aqueous suspensions and tinctures. MATERIALS AND METHODS A microemulsion was prepared using the dropwise addition method. Mouse skin fibroblasts were cultured in vitro to investigate the optimal conditions for evodiamine and rutaecarpine uptake with different drug concentrations a...

This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape wit...

BACKGROUND Rotigotine is a potent and selective D1, D2, and D3 dopaminergic receptor agonist. Due to an extensive first-pass effect, it has a very low oral bioavailability (approximately 0.5% in rats). PURPOSE The present investigation aimed to develop a microemulsion-based hydrogel for transdermal rotigotine delivery with lower application site reactions. METHODS Pseudoternary phase diagra...

The microemulsion is the emulsion with dimension of molecules approx. micrometre and smaller. Such microemulsion of water and diesel oil creates new quality and lets on obtainment ecological and economic of effects, as well as eliminates the disadvantageous influence common emulsions, or unprofitable effects of the injection of water to inlet system of the engine, direct to combustion chambers,...

The Essential oil (EO) of Nigella sativa (black cumin) was extracted from the crude oil and the volatile constituents were characterized using gas chromatographic analysis. The EO was formulated in water-based microemulsion system and its antibacterial activity against six pathogenic bacteria was evaluated using the agar well diffusion method. This activity was compared with two other well know...

This tutorial review first details the uncontrolled microemulsion polymerization mechanism, and the RAFT polymerization mechanism to provide the necessary background for examining the RAFT microemulsion polymerization mechanism. The effect of the chain transfer agent per micelle ratio and the chain transfer agent aqueous solubility on the RAFT microemulsion polymerization kinetics, polymer mole...

Fexofenadine (FEX) has high solubility and low permeability (BCS, Class III). In this work, novel FEX loaded water in oil microemulsion (w/o) was designed to improve bioavailability and compared with Fexofen(®) syrup in in vitro and in vivo studies. In addition, pharmacokinetic parameters in permeability studies were estimated by using WinNonLin software program. w/o microemulsion system was op...